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Uedu Open / Systems Biology
8.591J

Systems Biology

Prof. Jeff Gore | Fall 2014
Science & Math Biology Physics Engineering Biological Engineering Cell Biology Computation and Systems Biology Science
Go to original course
CC BY-NC-SA 4.0
Course introduction
This course provides an introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology.
Course Information
SourceMIT 開放式課程
DepartmentBiology
LanguageEnglish
Number of videos24
Course videos (24)
1
Introduction to the Class and Overview of Topics
Introduction to the Class and Overview of Topics
2
Input Function, Michaelis-Menten kinetics, and Cooperativity
Input Function, Michaelis-Menten kinetics, and Cooperativity
3
Autoregulation, Feedback and Bistability
Autoregulation, Feedback and Bistability
4
Synthetic Biology and Stability Analysis in the Toggle Switch
Synthetic Biology and Stability Analysis in the Toggle Switch
5
Oscillatory Genetic Networks
Oscillatory Genetic Networks
6
Graph Properties of Transcription Networks
Graph Properties of Transcription Networks
7
Feed-forward Loop Network Motif
Feed-forward Loop Network Motif
8
Introduction to Stochastic Gene Expression
Introduction to Stochastic Gene Expression
9
Causes and Consequences of Stochastic Gene Expression
Causes and Consequences of Stochastic Gene Expression
10
Stochastic Modeling
Stochastic Modeling
11
Life at Low Reynolds Number
Life at Low Reynolds Number
12
Robustness and Bacterial Chemotaxis
Robustness and Bacterial Chemotaxis
13
Robustness in Development and Pattern Formation
Robustness in Development and Pattern Formation
14
Microbial Evolution Experiments and Optimal Gene Circuit Design
Microbial Evolution Experiments and Optimal Gene Circuit Design
15
Evolution in Finite Populations
Evolution in Finite Populations
16
Clonal Interference and the Distribution of Beneficial Mutations
Clonal Interference and the Distribution of Beneficial Mutations
17
Fitness Landscapes and Sequence Spaces
Fitness Landscapes and Sequence Spaces
18
Evolutionary Games
Evolutionary Games
19
Survival in Fluctuating Environments
Survival in Fluctuating Environments
20
Parasites, the Evolution of Virulence and Sex
Parasites, the Evolution of Virulence and Sex
21
Interspecies Interactions
Interspecies Interactions
22
Ecosystem Stability, Critical Transitions, and Biodiversity
Ecosystem Stability, Critical Transitions, and Biodiversity
23
Dynamics of Populations in Space
Dynamics of Populations in Space
24
The Neutral Theory of Ecology
The Neutral Theory of Ecology